Identification of HHV8 in early Kaposi's sarcoma: implications for Kaposi's sarcoma pathogenesis
نویسندگان
چکیده
منابع مشابه
Kaposis sarcoma in a Nairobi hospital.
BACKGROUND Kaposi's sarcoma (KS) is associated epidemiologically with HIV infection and a number of countries have reported a dramatic increase in the incidence of KS with the advent of AIDS. Although AIDS is prevalent in Kenya, no studies on the impact of AIDS on the pattern of KS has been carried out. OBJECTIVE To determine any changes in the pattern of KS that might have occurred since the...
متن کاملIdentification of HHV8 in early Kaposi's sarcoma: implications for Kaposi's sarcoma pathogenesis.
AIMS Kaposi's sarcoma is a vascular tumour of uncertain pathogenesis possibly caused by an infectious agent, identified in high risk groups. Accumulating solution phase polymerase chain reaction (PCR) and seroepidemiological data suggest that a previously undescribed herpes DNA virus (human herpesvirus 8 (HHV8)) is the causative agent. Using a unique cohort of early Kaposi's sarcoma, the precis...
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Radiation induced sarcoma is a rare but recognized complication of radiotherapy and is associated with poor prognosis, frequently occurs 5 years after completion of treatment. We report radiation-induced sarcoma in a 42 years old male, involving the left parietooccipital scalp region following treatment of brain tumor with craniotomy and post-operative radiation with 60Co machine. Diagnosis of ...
متن کاملCyclin D1 expression and HHV8 in Kaposi sarcoma.
BACKGROUND Human herpesvirus 8 (HHV8) appears to be the agent responsible for Kaposi sarcoma. The mechanism remains undetermined but may involve cell cycle regulating genes including D type cyclins which are pivotal in cell cycle progression. Recent HHV8 genetic analysis has revealed the presence of a v-cyclin which is homologous to D type cyclins. AIMS First, to assess whether there is an in...
متن کاملNucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8).
The genome of the Kaposi sarcoma-associated herpesvirus (KSHV or HHV8) was mapped with cosmid and phage genomic libraries from the BC-1 cell line. Its nucleotide sequence was determined except for a 3-kb region at the right end of the genome that was refractory to cloning. The BC-1 KSHV genome consists of a 140.5-kb-long unique coding region flanked by multiple G + C-rich 801-bp terminal repeat...
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ژورنال
عنوان ژورنال: Molecular Pathology
سال: 1998
ISSN: 1366-8714
DOI: 10.1136/mp.51.1.14